The General Hospital Corporation

University of Rochester

Laura Maria Calvi

David T Scadden

Henry M Kronenberg

Gregor Adams

Regis James O'Keefe

Regis O'Keefe

Henry Kornenberg

Described herein are methods, compositions and kits related to manipulating hematopoietic stem cells and more particularly to methods, compositions and kits related to increasing the number of hematopoietic stem cells in vitro and in vivo. Also described are methods, compositions and kits related to making an expanded population of hematopoietic stem cells (HSCs) and methods, compositions and kits related to using the expanded population of HSCs.

Expansion of hematopoietic stem cells

The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.

Parathyroid hormone receptor activation and stem and progenitor cell expansion

The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.

Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion

Growing community of inventors

Rochester, NY, United States of America

Laura Maria Calvi