Centre National De La Recherche Scientifique

Galderma Holding Sa

Galderma Research & Development

Nestle Skin Health Sa

Laura Jing Jing

Craig Steven Harris

Jean-Guy Boiteau

Thibaut Gerfaud

Rachel Auzely-Velty

Tamiris Figueiredo

Anders Karlsson

Elin Säwén

Loïc Tomas

A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.

Method of crosslinking glycosaminoglycans

A method for cleaving amide bonds, comprising:

Method for cleaving amide bonds

A method for cleaving amide bonds, including: a) providing a molecule including an amide group; b) reacting the molecule including the amide group with a hydroxylamine salt to cleave the amide bond of the amide group. The method may further include c) recovering a product formed by the reaction of step b).

A method of preparing a sterilized injectable hydrogel composition, including the steps: a) covalently crosslinking a glycosaminoglycan using a bi- or polyfunctional crosslinking agent to form a covalently crosslinked glycosaminoglycan, b) swelling the covalently crosslinked glycosaminoglycan in a solution including a divalent cation to form a hydrogel composition, and c) sterilizing the hydrogel composition by autoclaving to form a sterilized injectable hydrogel composition, and to sterilized injectable hydrogel compositions obtainable by such method.

Hyaluronic acid gel with a divalent zinc cation

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Antibes, France

Laura Jing Jing