Bioventures, LLC

Arkansas Children's Research Institute

Other

Laura James

Dean W Roberts

Jack Hinson

Pritmohinder S Gill

Eric James

The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts.

Acetaminophen adducts and methods of use thereof

The present disclosure provides isolated antibodies that bind to acetaminophen-protein adducts that are useful in the detection and diagnosis of acetaminophen-induced toxicity.

Anti-acetaminophen antibodies and acetaminophen protein adducts

The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.

Disclosed is a drain blockage responsive alarm system. The drain blockage responsive alarm system comprises a cleanout cap member, at least one drain blockage responsive element, and an alarming module. The cleanout cap member is capable of being installed at a portion of a drain pipe. Further, the at least one drain blockage responsive element is configured to the cleanout cap member adapted to sense clog deposition at the portion of the drain pipe, and to generate an output signal upon sensing the clog deposition. Furthermore, the alarming module is electrically coupled to the at least one drain blockage responsive element for generating an alarm signal upon receiving the output signal.

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Little Rock, AR, United States of America

Laura James