University of Pittsburgh

The Scripps Research Institute

Laura J Niedernhofer

Paul David Robbins

Peter Wipf

Johnny Huard

Mitra Lavasani

Theodore M Kamenecka

Gabriela Mustata Wilson

The invention is directed to a method of inhibiting, within a living cell, the interaction between NF-&#x3ba;B essential modulator ('NEMO') with I&#x3ba;B kinase-&#x3b2; (IKK-&#x3b2;) at the NEMO binding domain (NBD), comprising exposing the cell to an effective amount or concentration of a compound of the invention, a NEMO-binding domain analog (NBDA). The invention is further directed to a method of treating a condition in a patient, wherein inhibiting the interaction between NF-&#x3ba;B essential modulator ('NEMO') with I&#x3ba;B kinase-&#x3b2; (IKK-&#x3b2;) at the NEMO binding domain (NBD) is medically indicated, comprising administering to the patient an effective dose of a compound of the invention. Conditions that can be treated by a method of the invention includes muscular dystrophy, asthma, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, arthritis, diabetes, graft versus host disease, accelerated aging, heart ischemia, cancer, UV-induced skin damage, or an age-related pathology.

Small molecule analogs of the nemo binding peptide

The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. 'Inhibiting a sign of aging or degenerative disorder' means reducing the risk of occurrence, delaying the onset, slowing the progression, and/or reducing the severity and/or manifestation, of a sign of aging or degenerative disorder, and includes, but is not limited to, preventing the occurrence, development or progression of a sign of aging or degenerative disorder.

Compounds for the treatment of pathologies associated with aging and degenerative disorders

This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or improves health of the mammal. In addition, the invention also relates to compositions containing one or more regulatory factors secreted or released from isolated mammalian stem/progenitor cells and use of such compositions to extend lifespan and/or improve health of a mammal. Also provided are methods of treating, delaying, preventing or reversing progeria or related syndromes in a mammal using isolated autologous or allogeneic stem/progenitor cells and/or regulatory factors secreted or released therefrom.

Compositions and methods for restoring or rejuvenating stem/progenitor cell function

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Pittsburgh, PA, United States of America

Laura J Niedernhofer