Massachusetts Institute of Technology

The General Hospital Corporation

Panther Therapeutics, Inc.

Laura Indolfi

Robert Samuel Langer

Elazer Reuven Edelman

Robert S Langer, Jr

David T Ting

Robert S Langer

Jeffrey W Clark

Matteo Ligorio

Cristina Rosa Annamaria Ferrone

Margaret Lashof-sullivan

Cristina Rosa Ferrone

Elazer R Edelman

Provided are implantable and biodegradable drug delivery devices capable of delivering an active pharmaceutical ingredient (API) directly to a target tissue site. The drug delivery devices can include at least two layers. One of the layers can include the API and a biodegradable polymer and a second layer can include another biodegradable polymer that degrades slower than the first biodegradable polymer. When the device is placed directly on the target tissue, the API layer can degrade thereby releasing the API towards the target tissue while the non-API layer can prevent the API from being released away from the target tissue onto non-target tissue.

Implantable and biodegradable drug delivery devices and methods of use thereof

Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 &#x3bc;m to about 1000 &#x3bc;m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

Local drug delivery devices and methods for treating cancer

Growing community of inventors

Boston, MA, United States of America

Laura Indolfi