Centre National De La Recherche Scientifique

Laura Fourmois

Boris Vauzeilles

Jordi Mas Pons

Aurélie Baron

Disclosed is a method of preparation of 6-azido-2,4-diacetamido-2,4,6-trideoxy--mannose. This method includes the chemical reaction of compound of formula X: Wherein: Rcan be a Cto Calkyl including methyl, ethyl, isopropyl; aryl including phenyl; each of these groups being substituted or not; and Rcan be a Cto Calkyl including methyl, ethyl, isopropyl, tert-butyl, isobutyl; each of these groups being substituted or not; with a deprotecting reagent including a Lewis or Br&#xf6;nsted acid in a polar aprotic solvent, thereby obtaining a free C-1 OH group. The method can also start with the preparation from commercially available-galactose pentaacetate,-galactose tetraacetate or tetraacetyl-galactosyl trichloroacetimidate. The step of deprotecting the anomeric position avoids the use of cerium and allows the easy purification of 6-azido-2,4-diacetamido-2,4,6-trideoxy--mannose.

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Buchelay, France

Laura Fourmois