Solta Medical, Inc.

University of California

University of Utah Research Foundation

The Salk Institute

Laura England

Dragan Danilo Nebrigic

Marlo Cinco

Herb Lara

Richard Hatch

Igor Leonidovich Tchertkov

Kai Nakamura

Baldomero M Olivera

J Michael McIntosh

Lourdes J Cruz

David J Julius

Elsie C Jimenez

A Grey Craig

Jean A Rivier

Apparatus and methods for delivering electromagnetic energy to a patient's tissue with a reduction in the pain experienced by the patient. The tissue treatment apparatus includes a delivery device configured to transfer electromagnetic energy through the skin surface to a region of tissue and a vibration device mechanically coupled with the delivery device. The vibration device is configured to transfer mechanical vibrations through the skin surface to the region of tissue.

Tissue treatment apparatus with functional mechanical stimulation and methods for reducing pain during tissue treatments

The present invention is directed to conopeptides having 6-45 amino acids, including one or more bromo-tryptophan residues. More specifically, the present invention is directed to conopeptides having the general formula: R-(Cys).sub.n -R.sup.1 -B-R.sup.2 -Cys-R.sup.3, wherein R is a peptide chain of 0-24 amino acids, R.sup.1 is a peptide chain of 0 to 31 amino acids, R.sup.2 is a peptide chain of 0-29 amino acids, R.sup.3 is a peptide chain of 0 to 26 amino acids, B is 6-bromo-tryptophan, n is 0 or 1 and the total length of the conopeptide is from about 6 to about 45 amino acids. The invention also includes pharmaceutically acceptable salts of the conopeptides. These bromo-tryptophan containing conopeptides invention are useful as antihelminthic agents, anti-vomiting agents, sleep-inducing agents, adjuncts to anesthesia, anticonvulsant or neuroprotective agents.

Bromo-tryptophan conopeptides

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Alameda, CA, United States of America

Laura England