Washington University

Laura Dugan

Kevin L Quick

Eva G Lovett

Joshua I Hardt

Robert H Mach

Wenhua Chu

Dennis W Choi

Tien-yau Luh

Tien-Sung Tom Lin

Mark Mintun

Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.

Dihydroethidine analogues and uses thereof

Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula CR, wherein each R is independently selected from groups of the formula &#x2550;CRRwherein each Rand Ris independently selected from the group consisting of &#x2014;H and &#x2014;COOH, provided, however, that at least one of the R's and R's is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.

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Disclosed and claimed herein are e, e, e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula CR, wherein each R is independently selected from groups of the formula &#x2550;CRRwherein each Rand Ris independently selected from the group consisting of &#x2014;H and &#x2014;COOH, provided, however, that at least one of the Rs and Rs is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.

A method of treating neurotoxic injury, where the injury is the result of the release of oxygen-derived free radicals, is disclosed. The method utilizes carboxyfullerenes as free radicals scavengers to reduce the damage caused by the free radicals.

Growing community of inventors

San Diego, CA, United States of America

Laura Dugan