Alphavax, Incorporated

Liquidia Technologies, Inc.

Laura Copp

Jonathan F Smith

Bolyn Hubby

Whitney Ellis

Peter Berglund

Andrew Murphy

Samantha Roth

Jeff Kindig

Ashley Galloway

Jesse White

The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an alphavirus replicon particle which expresses the same antigen. This allows for the use of significantly smaller quantities of the protein antigen than in conventional immunization strategies, and this new immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.

Alphavirus replicon particles matched to protein antigens as immunological adjuvants

The immune response to an antigen of interest, either in purified form or expressed via an alphavirus replicon particle, can be enhanced by the simultaneous administration of an alphavirus replicon particle which expresses interleukin-12. This allows for the use of significantly smaller quantities of the antigen and this immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.

Alphavirus replicon particles as immunological adjuvants

Growing community of inventors

Raleigh, NC, United States of America

Laura Copp