Merck Sharp + Dohme Corp.

Laura Catherine Cooper

Ian James Collins

Timothy Harrison

Angus Murray MacLeod

Jose Luis Castro Pineiro

Andrew Madin

Kevin J Wilson

Monique Bodil Van Niel

Tamara Ladduwahetty

Kevin John Merchant

Mark Peter Ridgill

Peter Alan Hunt

Linda Elizabeth Keown

Alexander Charles Humphries

Myra Gilligan

Angus Murray Macleod

Kevin Wilson

Compounds of formula I: are potent and selective antagonists of the human 5-HTreceptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Diarylsulfones as 5-HT2A antagonists

Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase

Compounds of formula I: wherein X represents a 5-(R-substituted)-1,2,4-oxadiazole-3-yl moiety are inhibitors of gamma-secretase, and hence useful for treating Alzheimer's disease 

Oxadiazole derivatives for inhibition of gamma secretase

Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease

Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase

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Puckeridge, United Kingdom

Laura Catherine Cooper