Mersana Therapeutics, Inc.

Laura C Akullian

Russell Colyn Petter

Aleksandr V Yurkovetskiy

Cheri A Stevenson

Mao Yin

Charles E Hammond

John J Kane

John Henry Van Duzer

Timothy B Lowinger

Gui Liu

Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.

Polyal drug conjugates comprising variable rate-releasing linkers

Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

Biocompatible biodegradable fumagillin analog conjugates

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Belmont, MA, United States of America

Laura C Akullian