Farmitalia Carlo Erba S.r.l.

Farmitalia Carlo Erba

Laura Bergonzoni

Paolo Sarmientos

Antonella Isacchi

Romeo Roncucci

Guy Mazue

Gilles Cauet

The present invention relates to the production, by recombinant DNA techniques, of derivatives of basic fibroblast growth factor (bFGF). These derivatives of bFGF can act as antagonists and/or superagonists of the wild type molecule in the angiogenic process. These derivatives, as well as wild type bFGF, may be prepared by the use of strains or E. coli which have been transformed with plasmids carrying nucleotide sequence coding for human and bovine bFGF and their derivatives.

Deletion mutant of basic fibroblast growth factor and production thereof

The present invention provides a polypeptide which is capable of binding specifically human basic fibroblast growth factor and human acidic fibroblast growth factor, a DNA sequence which encodes the polypeptide of the invention and a vector which incorporates a DNA sequence of the invention and which is capable, when provided in a transformed host, of expressing the polypeptide of the invention encoded by the DNA sequence. A host transformed with such a vector forms part of the invention also.

Extracellular form of the human fibroblast growth factor receptor

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Milan, Italy

Laura Bergonzoni