Sanofi

Sanofi-aventis

Laura Barzaghi

Roberto Cecchi

Umberto Guzzi

Tiziano Croci

Philippe Bovy

Stefano Romagnano

Nunzia Viviani

The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a &#x2014;S(O)(C&#x2013;C)Alk wherein z is 0, 1 or 2, a &#x2014;NHSO(C&#x2013;C)Alk, &#x2014;SONH(C&#x2013;C)Alk, &#x2014;NHSO&#x2014;(C&#x2013;C)Alk-phenyl or &#x2014;NHSO-phenyl group, said phenyl capable of bearing a halogen atom, a (C&#x2013;C)Alk group or a (C&#x2013;C)alkoxy group; Rrepresents a hydrogen atom or a &#x2014;(C&#x2013;C)Alk, &#x2014;CO(C&#x2013;C)Alk, &#x2014;(C&#x2013;C)Alk-phenyl or &#x2014;CO-phenyl group, said phenyl capable of bearing a halogen atom or a &#x2014;(C&#x2013;C)Alk or (C&#x2013;C)alkoxy group; Ris a hydrogen atom, a &#x2014;SO(C&#x2013;C)Alk, &#x2014;SO&#x2014;(C&#x2013;C)Alk-phenyl, &#x2014;SO-phenyl group, or a &#x2014;(C&#x2013;C)Alk group; X completes a saturated or unsaturated cycle of 5 to 8 atoms, capable of bearing one or two &#x2014;(C&#x2013;C)Alk groups and/or two carbonyl groups; Rand R'represent each independently a hydrogen or halogen atom, a &#x2014;(C&#x2013;C)Alk, hydroxy, &#x2014;CN, &#x2014;(C&#x2013;C)alkoxy, &#x2014;CORor Y&#x2014;CRR&#x2014;CORgroup; Y represents O or CH; Rrepresents a hydroxy, (C&#x2013;C)alkoxy or &#x2014;NRRgroup; Rand Rindependently represent a hydrogen atom, a &#x2014;(C&#x2013;C)Alk, group, aryl or heteroaryl optionally substituted by a Rgroup, aralkyl or heteroaralkyl optionally substituted by a Rgroup; or Rand R, with the nitrogen atom which bears them, form a saturated or unsaturated cycle of 5 to 7 atoms optionally substituted by a Rgroup; and Rrepresents a hydrogen or halogen atom, a hydroxy, &#x2014;(C&#x2013;C)Alk, &#x2014;(C&#x2013;C)alkoxy, &#x2014;NH(C&#x2013;C)Alk, &#x2014;N(C&#x2013;C)Alk, &#x2014;COO(C&#x2013;C)Alk, aralkyl or heteroaryl group; Rand Rindependently represent a hydrogen atom or a &#x2014;(C&#x2013;C)Alk group; their salts or solvates, the pharmaceutical compositions containing them, a method for preparing them and synthesis intermediates  

Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same

The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action.

Propanolaminotetralines, preparation thereof and compositions containing same

The present invention relates to an enzymatic process for the preparation of optically active tetrahydro-2-naphthoic acids from the corresponding racemic esters by reaction with a lipase.

Enzymatic process for the preparation of optically active tetralin

Enzymatic process for the preparation of optically active

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Monza, Italy

Laura Barzaghi