New York University

Spheryx, Inc.

Laura A Philips

David G Grier

Fook Chiong Cheong

David B Ruffner

Chen Wang

Michael D Ward

Xiao Zhong

Jesse J Elliott

Mary Ann Odete

Annemarie Winters

Holographic Video Microscopy analysis of non-spherical particles is disclosed herein. Properties of the particles are determined by application of light scattering theory to holography data. Effective sphere theory is applied to provide information regarding the reflective index of a sphere that includes a target particle. Known particles may be co-dispersed with unknown particles in a medium and the holographic video microscopy is used to determine properties, such as porosity, of the unknown particles.

Holographic characterization of irregular particles

Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.

Holographic characterization of protein aggregates

Impurities within a sample are detected by use of holographic video microscopy. The sample flows through the microscope and holographic images are generated. The holographic image is analyzed to identify regions associated with large impurities in the sample. The contribution of the particles of the sample to the holographic images is determined and the impurities are characterized.

Holographic detection and characterization of large impurity particles in precision slurries

Growing community of inventors

New York, NY, United States of America

Laura A Philips