Biodex

Latifa Dahri

Jacqueline Jozefonvicz

Marcel Jozefowicz

Frederic Chaubet

Remi Huynh

Jose Correia

The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMC B SU S , in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or &gE;0.3, b being equal to 0 or &gE;0.1, c being equal to 0 or &gE;0.1 and d being equal to 0 or &gE;0.1 provided that when d&equals;0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gauss elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.

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Saint-Amand-les-Eaux, France

Latifa Dahri