Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Egyt Gyogyszervegyeszeti Gyar

Mta Kozponti Kemial Kutato Intezete

Biocal Cyogyszergvar

Mta Kozponti Kemiai Kutato Intezete and Biogal Gyogyszergyar

Laszlo Tvos

Attila Szemzo

Janos Sagi

Helga Tudos Nee Feuer

Anna Szabolcs Nee Borbas

Sandor Jancso

Gyorgy Bacsa

Istvan Csernus

Katalin Marossy

Eva Medgyesi Nee Lukacs

Istvan Szinai

Zsuzsa Veres

Miklos Vajda

Laszlo Szporny

Eva Palosi

Lajos Kisfaludy

Istvan Horvath

Adam Sarkadi

Sandor Eckhardt

Janos Sugar

Laszlo Institoris

Janos Nagy

Sandor Kerpel-Fronius

Ildiko Fritzsche Nee Lukacs

Pal Ivan

Istvan Koczka

Csilla Rethati

Maria Peredy Nee Kajtar

Zsuzsanna Tegyei

Erno Moravcsik

Agnes Patthy Nee Lukats

Ivan Hidy

Somfai Relle

Katalin De Gleria

Ilona Elekes

Kalman Medzihradsz

Hedvig Medzihradszky-Schweiger

A method of treating herpes eye infections with an ophthalmic composition comprising 5-propyl-2'-deoxyuridine.

Method of treating herpes eye infections with 5-propyl-2'-deoxyuridine

The invention relates to an externally applicable, antiviral pharmaceutical composition accumulating in the skin for treating herpes infections, which composition comprises 0.2-5% by mass of 5-isopropyl-2'-.beta.-deoxyuridine admixed with carriers, diluents and/or other additives conventionally used in the production of pharmaceutical compositions for external use.

Topical process for treating herpes infections using 5-isopropyl-2'-.beta.-

The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, ##STR1## wherein R.sup.1 stands for a hydrogen atom, C.sub.1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C.sub.1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, ##STR2## wherein R is identical with R.sup.1, except where R.sup.1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V ##STR3## and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.

Process for the preparation of 5-(2-bromovinyl)-uridine

The invention relates to new hexitols having the general formula (I) and (II), ##STR1## wherein the hexitol skeleton is dulcitol, mannitol or iditol,

Hexitols containing free carboxy groups and a process for the

The invention relates to new tetrahydro-1,2,4-oxadiazin-5-one derivatives having a CNS activity. More particularly, the invention concerns new N.sup.4 -substituted tetrahydro-1,2,4-oxadiazin-5-ones of the formula (1) ##STR1## wherein R.sup.2 is benzyloxycarbonyl or alkylcarbonyl containing 1 to 4 carbon atoms in the alkyl moiety, preferably acetyl;

N4-Substituted tetrahydro-1,2,4-oxadiazin-5-one derivatives having

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Budapest, Hungary

Laszlo Tvos