Basf Aktiengesellschaft

Abbott Laboratories Corporation

Knoll Aktiengesellschaft

Knoll Atkiengesellschaft

Laszlo Szabo

Liliane Unger

Hans P Hofmann

Hans-Peter Hofmann

Wilfried Lubisch

Gerd Steiner

Hans-Joerg Treiber

Francisco Javier Garcia-Ladona

Berthold Behl

Manfred Raschack

Dorothea Starck

Rainer Schlecker

Franz Emling

Monika Knopp

Verena Baldinger

Uta Holzenkamp

Kurt Schellhaas

The invention relates to the use of binding partners for 5-HT5-receptors in the treatment of neuropathological and in particular neurodegenerative and/or neuropsychiatric disturbances which can occur notably in cases of cerebral ishcemia, cerebral stroke, epilepsy and attacks in general, chronic schizophrenia, other psychotic illnesses, dementia, notably Alzheimer's disease, demyelination diseases, notably multiple sclerosis and brain tumors. The invention also relates to methods, especially screening methods, for identifying and characterizing such binding partners.

Use of 5-ht5-ligands in the treatment of neurodegenerative and neuropsychiatric disturbances

Utilization of pyrimidine derivatives for preventing and treating cerebral ischaemia

Pyrrolylquinoxalinediones of the formula I

Pyrrolyl quinoxalindiones their production and use as AMPA receptor antagonists

Use of (S)-adenosyl-l-methionine (same) and its physiologically

1-aryl-4-piperazinylcyclohexanecarbonitriles, the preparation and use

2-hydroxy-3-phenoxy-propyl-substituted piperazines, their preparation

9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R.sup.3 and R.sup.4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R.sup.3 and R.sup.4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.

9-amino-2-phenylbicyclo[3.3.1]nonanes and

The use of (S)-emopamil and the salts thereof for the treatment of migraine is described.

(S)-emopamil for the treatment of migraine

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Dossenheim, Germany

Laszlo Szabo