Richter Gedeon Vegyeszeti Gyar Rt

Mta Kozponti Kemiai Kutato Intezete

Laszlo Rogdi

Laszlo Szporny

Eva Palosi

Lajos Kisfaludy

Szabolcs Szeberenyi

Julia Rohricht

Eszter Cholnoky

Helga Tudos Nee Feuer

Laszlo Otvos

Sara Ronai Nee Lukacs

Zsuzsanna Tegyey

Csilla Vezert Nee Solyom

The present invention relates to novel optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives of the formula ##STR1## methods for their preparation, pharmaceutical compositions comprising the said compounds as active ingredients and a method for the anticonvulsive treatment of mammals, especially human beings. The compounds of the formula I have as good activity as diphenyl hydantoine but their toxicity is much lower.

Novel anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives and

A tranquillo-sedative substituted 1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one of the formula (I), ##STR1## wherein R.sub.1 is halogen or nitro,

Tranquillo-sedative benzodiazepine derivatives

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Budapest, Hungary

Laszlo Rogdi