Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar

Richter Gedeon Vegyeszeti Gyar Rt

Muanyagipari Kutato Intezet

Egis Gyoryszergyar

Laszlo Pallos

Pal Benko

Lujza E Petocz

Gyorgy Hajos

Andras Messmer

Sandor Batori

Ibolya Kosoczky

Katalin Grasser

Eniko Szirt Nee Kiszelly

Karoly Magyar

Jeno Kovacs

Ildiko Simonek

Gabor Kovacs

Gabor Gigler

Istvan Gyertyan

Pal Fekete

Peter Tetenyi

Peter Tompe

Edit Berenyi Nee Poldermann

Peter Gorog

Laszlo Varga

Ildiko Ratz Nee Simonek

Agnes Kovacs Nee Palotai

Janos Gundel

Jeno Bernath

Tibor Zsolnai

Lajos Mahr

Maria Hegedus

Grasser Katalin

Laszlo Ladanyi

Eva Hartai Nee Zsorzs

Iren Zsolnai Nee Csillag

Marta Kininczky

Iren Barta

Andras Gelleri

Eva Toncsev, Nee Ravasz

Erzsebet Matrai

Zsuzsa Juhasz Nee Riedl

Albert Balogh

The new compounds of the general Formula I ##STR1## (wherein R.sub.1 stands for C.sub.1-4 alkyl or aralkyl; and

Condensed quinolinium and isoquinolinium derivatives

A process for the preparation of condensed as-triazinium derivatives of the formula I ##STR1## and isomers thereof, wherein R.sub.1 inter alia is an alkyl group, R.sub.2 inter alia is hydrogen or an alkyl group and R.sub.3 is hydrogen and where Z is a group of the formula a or b ##STR2## which comprises reacting a compound of the formula II ##STR3## where Y is a group of the formula c or d ##STR4## with a compound of the formula IIa

Process for the preparation of condensed as-triazine derivatives

The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier. The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 .mu.m with a high-energy irradiation in a dose of 1-15 Mrad--preferably with electrone radiation--and thereafter stretched at 80.degree.-90.degree. C. to a thickness of 2-200 .mu.m. The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.

Transdermal laminated pharamaceutical compositions having prolonged

The invention relates to new compounds of the general Formula I ##STR1## and isomers thereof wherein R.sub.1 is C.sub.1-10 alkyl, C.sub.3-6 cycloalkyl or phenyl, naphthyl or phenyl-(C.sub.1-4 alkyl), wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);

Condensed as-triazine derivatives

The invention relates to new phenanthrene derivatives wherein R stand for C.sub.1-10 alkylamino; C.sub.1-10 alkylthio; C.sub.1-5 alkoxy; or phenyl or phenylamino, the two latter groups being optionally substituted on the phenyl ring by one or more identical or different C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, cyano and/or halogen substituent(s) . The compounds of the present invention possess valuable fungicidal properties and may be used in agriculture, horticulture and therapy as active ingredient of fungicidal or antifungal compositions. The compounds of the general Formula I ##STR1## may be prepared by acylating 9,10-phenanthrene-dione-9-oxime or an alkali or alkali earth metal salt thereof.

Phenanthrene derivatives

A one step process for the preparation of compounds having antidepressant activity of the formula I ##STR1## and isomers thereof, wherein R.sub.1, R.sub.2, Z and A.sup.- have the meanings indicated in the claims, which process comprises: heating a compound of the formula II ##STR2## wherein Z, A.sup.-, R.sub.1 and R.sub.2 have the meanings set out in the claims and R.sub.3 stands for hydrogen or C.sub.1-4 alkyl, in the presence of a dehydrating agent to split off a compound of the formula R.sub.3 OH. The invention is also directed to compounds of the formula I, wherein R.sub.2 is halogen and to compositions containing a compound of the formula I which exhibit antidepressant activity.

The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy;

Quinoline derivatives and pharmaceutical compositions

2-Hydroxymethyl-quinoxaline-1,4-dioxide derivatives, a process for

The invention relates to new condensed as-triazine derivatives of the general formula (I) ##STR1## wherein Z represents a buta-1,3-dienyl group or a group of the formula (a), (b), (c) or (d) ##STR2## R.sub.1 denotes a C.sub.1-10 alkyl group, an oxo group or a C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) group optionally substituted by one or more identical or different substituents selected from the group consisting of amino, nitro, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,

Condensed as-triazine derivatives and method of using the same

Novel aminoisoquinoline derivatives of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,

Aminoisoquinoline derivatives

The invention provides 2-�(p-methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide. This compound is indicated for use as a potent antibacterial agent having a low toxicity.

2-�(P-Methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide

The invention relates to new quinoxaline-1,4-dione derivatives of the formula ##STR1## wherein R is pyridyl, 5-nitrofuryl or 1-naphthylmethyl group. The new compounds of formula I have weight-gain increasing effects.

Quinoxaline-1,4-dioxide derivatives

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Budapest, Hungary

Laszlo Pallos