Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Mta Kozponti Kemiai Kutato Intezete

Mta Zozponti Kemiai Kutato Intezet

Laszlo Otvos

Laszlo Szporny

Eva Palosi

Lajos Kisfaludy

Eszter Cholnoky

Attila Szemzo

Janos Sagi

Helga Tudos Nee Feuer

Laszlo Rogdi

Zoltan Vargay

Tivadar Palagyi

Katalin Ebinger

Iren Fellegvari

Karoly Payer

Istvan Gacs

Emilia Dobis Nee Farkas

Ottone Szabolcs

Sara Ronai Nee Lukacs

Gyula Sagi

Zsuzsanna Tegyey

Eva Ruff

Csilla Vezert Nee Solyom

Ferencne Tudos

Sandor Mlinko

Dezso Banfi

A 12 to 30 nucleotide-unit long oligonucleotide that comprises at least one 5-substituted uracil or cytosine, where the 5-substituent is a C.sub.3-6 n-alkyl, a vinyl, a butenyl, an ethynyl, or a C.sub.4-12 n-1-alkynyl, with the proviso that the uracil moiety may not be substituted with an n-alkyl or a C.sub.8-12 n-1-alkynyl.

Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and

The present invention relates to novel optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives of the formula ##STR1## methods for their preparation, pharmaceutical compositions comprising the said compounds as active ingredients and a method for the anticonvulsive treatment of mammals, especially human beings. The compounds of the formula I have as good activity as diphenyl hydantoine but their toxicity is much lower.

Novel anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives and

A process for measuring the isotope content of substances containing .sup.3 H or .sup.3 H and .sup.14 C isotopes in the gas phase, by converting the hydrogen content of the sample into water and the carbon content of the sample to a gaseous substance in simultaneous oxidation processes, separating the formed water and carbon dioxide, reconverting the .sup.3 H content of the water into gaseous form, introducing the gases containing .sup.3 H and possibly also .sup.14 C separately into a detecting unit, and determining the radioactivity of said gases, in which the tritium content of the water carrying the .sup.3 H radio-activity is bonded on a contact catalyst capable of water retention or adsorption and containing activated hydrogen, the gaseous mixture, containing also .sup.14 CO.sub.2 when a sample of .sup.14 C content is analyzed, is removed and, optionally after purification, is fed into a detecting unit together with a counting gas, then the tritium adsorbed on the surface of the catalyst is continuously converted into gas phase by exchange reaction with an appropriate gas flow and is fed into a detecting unit in unchanged state, or in the form of a compound prepared from it by chemical reaction.

Process and apparatus for measuring the isotope content of substances

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Budapest, Hungary

Laszlo Otvos