Temple University

The Wistar Institute

Allysta Pharmaceuticals, Inc.

Laszlo Otvos

Eva Surmacz

Walter U Gerhard

Henry Hsu

Dorothee Herlyn

Rajasekaran Somasundaram

Disclosed are ophthalmic compositions, methods for using the compositions and kits comprising the compositions for treating dry eye in a subject in need thereof. The composition comprises at least one peptide that is an inhibitor of trans-endothelial migration, an analogue, variant, derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient for treating dry eye and ocular diseases of inflammation.

Peptides for dry eye disease

Short peptide mimetics of adiponectin suitable for development as pharmaceutical agonists in the treatment of cellular proliferative disorders such as cancer and atherosclerosis are provided.

Adiponectin receptor agonists and methods of use

Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance, lipodystrophy and hypothalamic amenorrhea, obesity-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.

Leptin agonist and methods of use

This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used to inhibit leptin receptor activity, promote growth arrest or death of leptin receptor-positive cancer cells, or monitor or detect a leptin receptor-positive cell, in vitro or in vivo. These compounds may also be used to treat a weight-loss nutritional disorder, osteoporosis, rheumatoid arthritis, osteoarthritis, or inflammatory bowel disease. Also included in the invention are methods for detecting leptin receptor-positive cells, for arresting cell growth or killing cancer cells in vivo, for monitoring or detecting a leptin receptor-positive cell in vitro or in vivo, for treating a weight-loss nutritional disorder, for treating osteoporosis, for treating rheumatoid arthritis, for treating osteoarthritis, or for treating inflammatory bowel disease.

Leptin antagonist and methods of use

Antimicrobial peptides of the formula are provided: X&#x2014;X&#x2014;PrO&#x2014;X&#x2014;X&#x2014;PrO-Arg-Pro-Tyr-Leu-Pro-X-Pro-Arg-Pro-Pro-Arg-Pro-Y, wherein Xis a natural or non-natural amino acid having a free amino group or 1-amino-cyclohexyl carboxylic acid, Xis Arg or N-methyl-Arg, Xis Asp or GIu, Xis Arg or Lys, Xis Arg or Lys, and Y is Arg, Arg-NH2, N-methyl-Arg, N-methyl-Arg-NH, Val-Arg, Val-Arg-NH, Val-(N-methyl-Arg), or Val-(N-methyl)-Arg-NH, and salts thereof.

Antibacterial peptides active in systemic infections

Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.

Novel BRAFmutant peptides or a pharmaceutically acceptable salt thereof, that induce MHC Class I-dependent cytotoxic T cell responses in mammals are useful in prophylactic, diagnostic and therapeutic treatments for melanoma. Such compounds are also useful in drug development for non-peptide mimics of the compounds described herein and in the development of therapeutic or diagnostic antibodies.

Methods and compositions for treating melanoma

The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.

Composition and method for preventing or treating a virus infection

The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. The multiple antigenic agents of the invention contain at least one of a B cell determinant, a T cell determinant, or a targeting molecule attached to a core peptide composed of Lys-Gly repeats.

Multiple antigenic agents and methods for using the same

Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y&#x2032;-RSEQ ID NO: 1 or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti-bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.

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Audubon, PA, United States of America

Laszlo Otvos