Richter Gedeon Vegyeszeti Gyar Rt

Magyar Szenhidrogenipari Kutato-/fejleszto Intezet

Jonathan Mgtsz

Laszlo Nemeth

Karola Jovanovics

Kalman Szasz

Bela Kellner

Zsuzsa Relle

Emil Bittner

Eszter Dezseri

Eszter Deszeri

Sandor Doleschall

Bela Jover

Gyula Gati

Istvan Juhasz

Imre Sapi

Sandor Kovtacs

Gizella C Horvath

Pap Geza

The invention relates to a process for the production of alcohol-free wine, i.e. wine containing less than 1% by volume of alcohol, and of wines containing reduced concentrations i.e. 1 to 7% by volume of alcohol with the simultaneous production of brandy by using continuous vacuum film distillation with continuous introduction of carbon dioxide and/or an inert gas, producing thereby a dynamic atmosphere of carbon dioxide and/or an inert gas, at the temperature of at most 100.degree. C., preferably 40.degree.-100.degree. C. and in a vacuum of 6.45-25.80 kPa.

Product and process for production of alcohol-free wines or alcohol

N-formylleurosine or a pharmaceutically effective salt is used in human therapy for treatment of lymphoma, leukemia or Hodgkins Disease.

Method of treatment using new leurosine derivatives

Multiple myeloma in human patients is treated by administering N-formylleurosine or its sulfate salt.

New leurosine derivatives of the general formula (1), ##STR1## wherein R stands for hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt.

N-Formyl leurosine derivatives in a dosage form effective for treating

Leurosine derivatives of the formula (I), ##STR1## wherein R is hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt. The new compounds of the invention possess strong cytostatic activity, and can be used in the human therapy with great advantage.

N-formyl and N-desmethyl leurosine derivatives

Growing community of inventors

Budapest, Hungary

Laszlo Nemeth