Elan Pharmaceuticals, Inc.

Other

Warner-lambert Company

Neurex Corporation

Laszlo Nadasdi

Stephen S Bowersox

Balazs G Szoke

Laszlo Urge

George P Miljanich

Michael Francis Rafferty

Yuntao Song

Lain-Yen Hu

Thomas C Malone

Robert W Newcomb

Ruth L Cong

William F Hopkins

Diego F Silva

Katalin Tarczy-Hornoch

Andrew L Palma

Robin Dean

David T Connor

Bruce D Roth

Louis Brogley

Harriet W Hamilton

Richard John Booth

Wayne Livingston Cody

Jack D Barchas

Todd Robert Ryder

Robert S Bitner

John Xiaoqiang He

James L Miller

Glen R Elliott

Peter I Adriaenssens

Leonard Joseph Lescosky

A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.

Voltage-gated calcium channel antagonist and method

Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive sodium channels. Also disclosed is a novel class of compounds that is selective for blocking tetrodotoxin-insensitive sodium channels.

Analgesic screening method and composition

Peptidyl calcium channel blockers

Substituted peptidylamine calcium channel blockers

Compounds of formula I are useful for suppressing appetite, for altering macronutrient preferences, for suppressing obsessive-compulsive behavior, and for inhibiting cravings and substance abuse: ##STR1## wherein R.sub.1 and R.sub.3 are each independently H, hydroxy-alkyl, alpha-cyanoalkyl, SO.sub.3 H, SO.sub.2 NH.sub.2, or C(O)R, where R is OH, NH.sub.2, lower alkoxy, benzyloxy, or aliphatic amino acyl;

Method of suppressing appetite by administration of

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Walnut Creek, CA, United States of America

Laszlo Nadasdi