Nitrokemia Ipartelepek

Laszlo Legradi

Lajos T Nagy

Csaba Soptei

Zoltan Kolonics

Jeno Pelyva

Dezso Sebok

Pal Agocs

Elemer Tomordi

Bela Karacsonyi

Sandor Balint

Laszlo Lendvai

Andras Horvath

Judit Benczik Nee Pasztor

Ferenc Fodor, Deceased

K Istvan Vecsey

Jolan Cseke

Tibor Kranitz

Erzsebet Dioszegi

Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). ##STR1## wherein R is a C.sub.1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). ##STR2## wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80.degree. C. and 150.degree. C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate.

Process for preparing N-phenyl-N-methoxyacetyl-DL-alanine methyl ester

A process for preparing methoxyacetic acid by reacting monochloroacetic acid with sodium methylate, in a methanolic solvent at increased temperature. Methanol is distilled off and methoxyacetic acid methylester is added to the residue. The stirrable mixture is contacted with dry hydrochloric acid gas. The methoxyacetic acid methylester is distilled off after removing the precipitated sodium chloride, to recover the desired product.

Process for preparing methoxyacetic acid

Process for the preparation of

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Fuzfogyartelep, Hungary

Laszlo Legradi