Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Aktiebolaget Astra

Laszlo Ledniczky

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Tamas U Kallay

Csaba Gonczi

Gabor T Szabo

Ida Szvoboda Nee Kanzel

Eva Somfai

Maria Szomor Nee Wundele

Csaba Huszar

Judit Cser Nee Kun

Erzsebet Molnar Nee Bako

Attila Nemeth

Tibor Montay

Erzsebet Szalay

Ferenc Morasz

Karoly Ban

Istvan Bone

Gyorgy Lanyi

Ferenc Sperber

Erzsebet Szabo Nee Kardos

Sandor Garaczy

Gyorgy Mihalovics

Lajos Imrei

Karol Gyure

Gabor Kovacs

Judit Kun

Maria Sziladi

Robert Gepesz

Maria Szomor

Valeria Denes Nee Lustig

Ildiko Buttkai

Judit Cser

Ida Szvoboda

Csaba Gunczi

Ida Szvoboda Nee Kauzel

Gyorgy Hoffmann

Arpad Kvari

Peter Gyri

Mihaly Sut

Peter Gy Ri

Laszlo Rvai

Arpad K Vari

Iidiko Buttkai

Mihaly Su

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

Process for the preparation of substituted isoflavone derivative

Process for the preparation of ketone compounds

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

2-(3-phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

2-Cyano-2-(3-phenoxy-phenyl)-propionic acid amide and preparation thereof

2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

Process for the preparation of 2-(3-phenoxy-phenyl)-propionic acid

3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.

Process for the preparation of 3-phenoxybenzenes

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Budapest, Hungary

Laszlo Ledniczky