Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Laszlo Kopper

Karoly Lapis

Lajos Kisfaludy

Lajos Kovacs

Erno Tyihak

Bela Szende

Gyorgy Dobo

Kalman Medzihradszky

Andreas Jeney

Andras Jeney

Karoly Simon

Helga Suli

Hedvig Medzihradszky Nee Schweiger

The invention relates to new peptide derivatives of the general Formula I ##STR1## wherein R is a group derived from any oligopeptide by removing a terminal amino group, or--if the oligopeptide comprises a diamino carboxylic acid--the amino group in the .omega.-position, or the terminal and .omega.-amino groups; and

Nitroso-N-(.beta.-chloro ethyl)-carbamoyl peptides

There are disclosed pharmaceutical compositions comprising at least one cytostatic agent and N.sup..epsilon. -trimethylthyllysin or a pharmaceutically acceptable salt thereof, optionally in association with conventional pharmaceutical carriers and other additives. The new compositions possess a reduced toxicity compared with the cytostatic agents administered alone.

Pharmaceutical compositions and process for the preparation of same

Growing community of inventors

Budapest, Hungary

Laszlo Kopper