International Business Machines Corporation

The State University of New York

Laszlo Kando

David Clifford Long

Charles Hampton Perry

Glenn A Pomerantz

Keith C O'Neil

James Ralph Case

Thomas P Moyer

John E Kozol

Lorant Kovacs

Nandor Ludvig

Geza Medveczky

A minivalve for delivering one of a control solution or a drug solution to a point of interest in a freely moving animal. The minivalve is portable by the freely moving animal, such as a mouse, rat, or primate, on its head without interfering with its behavior. The minivalve having an input for a control solution and an input for a drug solution and further having a common output for outputting either of the control solution or drug solution to an input of a microdialysis probe implanted at a point of interest in the animal. Also provided are systems for delivering one of a control solution or a drug solution to a point of interest in the animal. The system comprises the minivalve, a drug ejection device such as a microdialysis probe or injection cannula implanted at the point of interest in the small animal, and a microelectrode placed adjacent to the drug ejection device. The minivalve is designed to be easily modified to be actuated with a gas or liquid, to be used in larger animals and in humans, to be mounted on body parts other than the head, to be used for drug delivery into other body organs than the brain, and to be integrated into various industrial/scientific instruments.

Miniature air-controlled drug selector and delivery device portable by small animals

A stress-free method and apparatus are provided for forming assemblies having thin substrates whereby a permanent non-interference fit low stress stud is positioned and secured evenly into a shallow hole of a thin substrate or host material without introducing uneven stress forces to maintain a flat surface on both sides of the thin substrate. The forces of inserting the stud are applied inward, towards a head portion of the tapered stud by a crimping tool adapted to move the substrate material inward and form a flange over the angled edges of the tapered head portion of the stud to secure the stud to the thin substrate. In doing so, the forces are absorbed by the strong tapered head portion of the stud which is able to withstand the crimping forces and will not be distorted by the inward crimping forces, thus maintaining flat surfaces of the substrate.

Concealed low distorting self crimping stud and insertion method

A method for testing the integrity at least two test objects, each object is made of a plastically deformable material, by a. contacting a moving means with the objects at a first point in time, the moving means at a first position and the objects at a first position, the moving means having a shaped portion; b. shifting at least a portion of the objects to a second position at a second time, subsequent to the first time, wherein at least a portion of the objects were displaced during the interval between the first time and the second time; c. evaluating the objects after the shifting in step b. 22.

Method and apparatus for the testing of plastically deformable objects

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Hopewell Junction, NY, United States of America

Laszlo Kando