Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Pharmaceutical and Chemical Works Ltd.

Laszlo Feuer

Arpad Furka

Ferenc Sebestyen

Mihaly Nogradi

Borbala Vermes

Aniko Horvath

Lorant Farkas

Sandor Antus

Agnes Gottsegen

Andras Wolfner

Erzsebet Bendefy Nee Dobay

Jolan Hercsel Nee Szepespataky

Janos Strelisky

Lorand Farkas

Janos Streliszky

Maria K Toth

Andreas Wolfner

Agnes Gettsegen

Jolan Hercsel, Nee Szepespataki

Maria Kovaks

Gyorgy Benko

Jolan Hercsel Nee Szepespataki

The invention is directed to a synergistic radiation protective pharmaceutical composition comprising 50 to 350 parts by weight of aminoalkyl-thiol-derivatives of the general formula II ##STR1## wherein R.sup.3 stands for hydrogen, or carboxamidino

Synergistic radiation protective pharmaceutical compositions

A process for preparing gamma-L-glutamyl-taurine, which has been found to be effective therapeutically through the control of vitamin A metabolism, which comprises reacting carbobenzyloxy-L-glutaminic acid-.alpha.-benzyl ester with triethylamine and isobutylchloroformate and then treating the reaction mixture with cystamine dihydrochloride to recover N,N'-bis-(N-carbobenzyloxy-gamma-[.alpha.-benzyl]-L-glutamyl)-cystamine. The latter is reacted with hydrogen peroxide in glacial acetic acid to produce carbobenzyloxy-gamma-(.alpha.-benzyl)-L-glutamyl taurine. The latter compound is treated with hydrogen bromide in glacial acetic acid to recover the gamma-(.alpha.-benzyl)-L-glutamyl taurine and this compound is treated with potassium hydroxide solution to yield the gamma-L-glutamyl taurine.

Method of preparing gamma-L-glutamyl taurine

A deproteinized, defatted aqueous extract of the parathyroid gland insoluble in benzene, chloroform and carbon tetrachloride is found to be L-gamma-glutamyl-taurine which has vitamin-A type activity and is generally effective for the treatment of a wide range of mammalian disorders which are directly or indirectly connected with pathological alterations of the aerobiospherical genetical adaptational system (AGAS).

L-gamma-glutamyl-taurine as extracted from parathyroid gland and method

The invention relates to novel .omega.-aminocarboxylic acid amides having the formula (I) ##STR1## wherein A is --SO.sub.2 OH or --OPO(OH).sub.2,

.omega.-Aminocarboxylic acid amides

An animal feed containing 0.00002 to 0.1% by weight of:

Animal feed containing anabolic isoflavones

Nonestrogenic 5-methyl-alkoxy-isoflavone, namely, 5-methyl-7-methoxy-isoflavone, 5-methyl-7-ethoxy-isoflavone, 5-methyl-7-isopropoxy-isoflavone, and 5-methyl-7-(2-hydroxy-ethoxy)-isoflavone are useful as weight-gain promoters in feeds from which the 7-methoxy and 7-ethoxy isoflavones have been excluded because of estrogenic effects. They are more effective than 7-isopropoxy-isoflavone as well.

Metabolic 5-methyl-isoflavone-derivatives, process for the preparation

Gamma-L-glutamyl cholamine phosphate and beta-L-aspartyl cholamine phosphates are disclosed, the compounds having blood-sugar-level lowering and serum vitamin A increasing effect.

Gamma-L-glutamyl cholamine phosphate

Compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof, wherein: A is --OPO(OH).sub.2 ;

.omega.-Aminocarboxylic acid amide phosphates

A deproteinized, defatted aqueous extract of the parathyroid gland insoluble in benzene, chloroform and carbontetrachloride. The composition has vitamin-A type activity and is generally effective for the treatment of irradiation injury.

Hormonal product extracted from parathyroid gland and process for the

A method of anabolic treatment in humans comprises administering a compound of the following formula: ##SPC1## Wherein R is halosubstituted, nitrosubstituted, or unsubstituted benzyl, R.sup.2 is hydrogen, methyl or carboxy, and R.sup.3 and R.sup.4 are hydrogen, methoxy or nitro. Pharmaceutical compositions are also disclosed.

Growing community of inventors

Budapest, Hungary

Laszlo Feuer