Richter Gedeon Vegyeszeti Gyar Rt

Laszlo Dobay

Janos Fischer

Laszlo Szporny

Elemer Ezer

Judit Matuz

Gyorgy Hajos

Tamas Fodor

Laszlo Czibula

Katalin Saghy

Eva Werkne Papp

Egon Karpati

Bela Kiss

Kalman Harsanyi

Bela Stefko

Janos Kreidl

Ferenc Trischler

Istvan Laszlovszky

Zsolt Szombathelyi

Andras Nemes

Istvan Borza

Istvan Hegedus

Ferenc Sebok

Judit Nagyne Bagdy

Ida Deutschne Juhasz

Juidit Nagyne Bagdy

Katalin Sz&ouml;ke

Sandor Leval

Tibor Wagner

Mihaly Major

One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 &#x3bc;m by diameter, whereas at least 99% of the particles are below 250 &#x3bc;m by diameter, and process for its preparation. A pharmaceutical composition comprising as active ingredient, high purity butoconazole nitrate of specified particle size in admixture with known auxiliaries is also within the scope of the invention. 

High purity butoconazole nitrate with specified particle size and a process for the preparation thereof

N-benzylpiperidine and tetrahydropyridine derivatives

The invention relates to a novel process of amalodipine benzenesulphonate of formula (I) by reacting a new 2-&lsqb;/2-carboxy-benzoyl)-aminoethoxy/methyl/&rsqb;-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-di-hydropyridine derivative of general formula (II) wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium&mdash;with benzenesulphonic acid.

Process for preparing amlodipine benzenesulphonate

Novel acrylic amide derivatives of the Formula (I) ##STR1## wherein R.sup.1 represents a hydrogen or a halogen atom or a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or a nitro group.

Amino acid containing acrylamide derivatives for ulcer prevention or

Novel acrylic acid salts of formula ##STR1## wherein R represents a hydrogen or a halogen atom, a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or a nitro group,

Novel acrylic acid salts, a process for their preparation,

The present invention relates to novel compounds of the general formula (I), ##STR1## wherein R stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or a C.sub.1-4 acylamino group; and

Novel salicylates, their salts, pharmaceutical compositions containing

The invention relates to novel butenoic acid derivatives of the general formula (Ia) having E-configuration ##STR1## as well as to their Z-izomers of the general formula ##STR2## wherein R stands for a (-)-menthyl or a (+)-menthyl group. as well as pharmaceutical compositions containing these compounds. The novel butenoic acid derivatives of the general formulae (Ia) and (Ib) possess valuable pharmacological properties, mainly gastric cytoprotective effect.

Butenoic acid derivatives, pharmaceutical compositions containing them

The present invention relates to a compound of the formula (I) ##STR1## wherein R.sup.1 stands for methyl or a group of the formula R.sup.3 --NH--(CH.sub.2).sub.4 --wherein R.sup.3 is hydrogen or a protective group being compatible with the peptide bond,

Alkylamino-furanon-derivatives

Growing community of inventors

Budapest, Hungary

Laszlo Dobay