Richter Gedeon Vegyeszeti Gyar Rt

Laszlo Denes

Laszlo Szporny

Gyorgy Hajos

Eva Palosi

Elemer Ezer

Gabor Bernath

Jeno Kobor

Istvan Schon

Ferenc Fulop

Gabor Motika

Lajos Kisfaludy

Olga Nyeki Nee Kuprina

Bela Szende

Olga Nyeki

Lajos Kisfaludy, Deceased

Pal Sohar

Alajos Kalman

Janos Lazar

Ferenc Folop

Pal Perjesi

Attila Sohajda

Lajos Kovacs

Maria Gazdag

Karoly Lapis

Imre Peter

Geza Ivanyi

Tamas Berhardt

Iidiko Berhardt

Gizella Lorant

Zsuzsanna Muck

Julia Ember

Kuprina O Nyeki

The present invention relates to a process for the preparation of high purity crystalline peptides Arg Lys Asp hydrate acetate and Arg Lys Asp Val from crude, amorphous peptides Arg Lys Asp and Arg Lys Asp Val hydrate acetate. The process is characterized in that

High purity crystalline peptides arglysasp and arglysaspval and a

Peptides are disclosed which inhibit the immune system. The peptides are selected from the group consisting of:

Novel peptides inhibiting the maturation of t-lymphocytes and the

Antileukemic and immunostimulant peptides

The invention relates to novel peptides and their acid addition salts, suppressing the function of the immune system, pharmaceutical compositions containing these peptides as well as to a process for preparing these peptides and compositions. The peptides are represented by formulae (1) to (16): ##STR1## The novel peptides are useful for the therapy of diseases where a decrease in the activity of the immune system is desirable.

Novel peptides suppressing the function of the immune system,

The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoquinol ine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms,

1-(6-(2'-substiuted-5', 6', 7',

The invention relates to new N-substituted bis(hydroxymethyl)-methyl-isoquinoline derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

N-substituted isoquinoline derivatives and pharmaceutical compositions

The invention relates to new 1-[bis(hydroxymethyl)-methyl]-3,4-dihydro- or -1,2,3,4-tetrahydroisoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

Isoquinoline derivatives, and pharmaceutical compositions containing them

The invention relates to new bis(substituted methyl)-methyl-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

Bis(substituted methyl)-methyl-isoquinoline derivatives and

The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

[1,3]oxazino[4,3-a]-isoquinoline derivatives and pharmaceutical

The invention relates to new 1-cyclohexyl-3,4-dihydroisoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents hydrogen, hydroxyl or alkoxy having from 1 to 6 carbon atoms,

1-cyclohexyl-3,4-dihydroisoquinoline derivatives and pharmaceutical

The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

2H-azeto[2,1-a]-isoquinoline derivatives and pharmaceutical compositions

The invention relates to 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or -thiazino-[4,3-a]isoquinoline derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 are alkoxy having from 1 to 6 carbon atoms,

1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or

Peptides affecting the immune regulation selected from the following group:

Growing community of inventors

Budapest, Hungary

Laszlo Denes