Richter Gedeon Vegyeszeti Gyar Rt

Richter Gedeon Nyrt.

Richter Gedeon Vegyeszeti Gmbh

Richter Gedeon Vegeyszeti Gyar Rt.

Laszlo Czibula

Janos Kreidl

Csaba Szantay

Gyorgy Visky

Egon Karpati

Andras Nemes

Maria Farkas Nee Kirjak

Ferenc Sebok

Laszlo Szporny

Lajos Szabo

Gyorgy Kalaus

Janos Galambos

Eva Againe Csongor

Katalin Nogradi

Balint Juhasz

Judit Nagyne Bagdy

Eva Werkne Papp

Sandor Farkas

Istvan Hegedus

Ida Deutschne Juhasz

Bela Kiss

Bela Stefko

Aniko Gere

Laszlo Dobay

Judit M Meszaros Nee Brill

Peter Hegyes

Sandor Foldeak

Szilvia Petofi-Vass

Eva Palosi

Kalman Harsanyi

Erzsebet Lapis

Gyorgy Domany

Dora Groo

Zsolt Szombathelyi

Katalin Csomor

Adam Sarkadi

Janos Fischer

Istvan Borza

Lilla Forgacs

Csaba Kuthi

Ferenc Auth

Andras Vedres

Adam Demeter

Istvan Vago

Maria Incze

Ida Nee Deutsch

Istvan Moldvai

Istvan Greiner

Gyorgyi Ignaczné Szendrei

Jánosné´ Kreidl Née Regina Hegedus, Legal Representative

Maria Farkas Nee Kirlyak

Ferencné Kassai

Maria Nee Farkas

Jenone Farkas

Mihaly Szegedi

Judit Brill, Deceased

Maria F Nee Kirjak

Ida D Nee Juhasz

Agnes Piller

Ildiko Ballo

Sandorné Balint

Tibor Bence Mathe

Laszlo Hegedus

Jen&ouml;me Farkas

Istvan Heged&uuml;s

Ferenc Sebök

Juidit Nagyne Bagdy

Denes Markos

Maria Zajer Nee Balazs

Ida Deutsch Nee Juhasz

Andras Szekeres

Margit Pellionisz Nee Paroczai

Maria Farkas Nee Kiriak

Laszlo Hegedues

The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein

Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester HCl

The invention relates to novel trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate and a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate, said process comprising the steps a) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)amino]-cyclohexyl}-acetic acid ester with sodium borohydride and aluminum trichloride to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethanol; b) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]cyclohexyl}-ethanol obtained with methanesulfonic acid chloride in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate; c) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate obtained with 2,3-dichlorophenyl-piperazine in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester;d) heating trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester obtained to a temperature between 40-100&#xb0; C. in a mixture of aqueous hydrochloric acid/methanol to give trans N-{4-{2-[4-(2,3-dichlorophenyl)piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate.

Piperazine salt and a process for the preparation thereof

The invention relates to a new process for the preparation of compounds of general formula (I) wherein Rand Rrepresent independently hydrogen or 

Process for the preparation of piperazine compounds and hydrochloride salts thereof

The invention relates to a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of general formula (I) by reacting the compound of formula (III) with a carbamoylchloride of general formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100&#xb0; C. in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.

Process for the preparation of piperazine derivatives

The present invention relates to novel monohydrochloride, dihydrochloride, monohydrobromide, maleate and methanesulphonate salts of trans 4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and/or their hydrates and/or solvates. Moreover, the invention relates to the process for preparing the salts and their hydrates and/or solvates, to their use in the treatment and/or prevention of conditions which require modulation of dopamine receptor and to pharmaceutical compositions containing them.

[object Object]

A process for preparing cabergoline (I) from ergoline-8&#x3b2;-carboxylic acid ester (XIII) comprising the following steps. (XIII), (XVI), (XVII), (XVIII), (XIX), (I). The present case also relates to the intermediates (XVI), (XVII), (XVIII) and (XIX) as well as the polymorphic amorphous form of Cabergoline (I) and the production thereof. 

Process for the preparation of cabergoline

One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 &#x3bc;m by diameter, whereas at least 99% of the particles are below 250 &#x3bc;m by diameter, and process for its preparation. A pharmaceutical composition comprising as active ingredient, high purity butoconazole nitrate of specified particle size in admixture with known auxiliaries is also within the scope of the invention. 

High purity butoconazole nitrate with specified particle size and a process for the preparation thereof

A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of 

Process for preparing monohydrate and crystal modifications of fluconazole

Process for the synthesis of a known tetrazol derivative

N-benzylpiperidine and tetrahydropyridine derivatives

Trans apovincaminic acid ester derivatives

Substituted propane-2-OL derivatives

Process for the preparation of

A method of treating a mammalian subject for Parkinson's disease or to provide a central muscle relaxant effect, which comprises the step of administering to the mammalian subject in need of the treatment, a therapeutically effective amount of a compound of the Formula (I) ##STR1## wherein m is 1,2 or 3;

Organosilane derivatives, pharmaceutical compositions containing them

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Budapest, Hungary

Laszlo Czibula