Avexxin As

Kappa Bioscience As

Borregaard Industries Limited

Lars Skattebol

Berit Johansen

Marit Anthonsen

Wenche Sjursen

Anne Kristen Holmeide

Marcel Sandberg

Inger Reidun Aukrust

Yngve Stenstrom

Ingger Riedun Aukrust

Berit Department Of Biology Johansen

Marit Department Of Biology Anthonsen

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I)  

Process for the preparation of vitamin K2

Psoriasis is a common, chronic, inflammatory skin disorder. This invention provides the use of a compound of formula (I) R&#x2014;CO&#x2014;X (Wherein R is a Cunsaturated hydrocarbon group optionally interrupted &#x3b1;, &#x3b2;, &#x3b3;, or &#x3b4; to the carbonyl group by a heteroatom or group of heteroatoms selected from S, O, N, SO, SOsaid hydrocarbon group comprising at least 5 non-conjugated double bonds; and X is an electron withdrawing group) in the manufacture of a medicament for the treatment of psoriasis.

Use of polyunsaturated ketones for the treatment of psoriasis

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst. 

Psoriasis is a common, chronic, inflammatory skin disorder. This invention provides the use of a compound of formula (I) R&#x2014;CO&#x2014;X (Wherein R is a Cunsaturated hydrocarbon group optionally interrupted by &#x3b1;, &#x3b2;, &#x3b3;, or &#x3b4; to the carbonyl group by a heteroatom or group of heteroatoms selected from S, O, N, SO, SOsaid hydrocarbon group comprising at least 5 non-conjugated double bonds; and X is an electron withdrawing group) in the manufacture of a medicament for the treatment of psoriasis.

Psoriasis is a common, chronic, inflammatory skin disorder. This invention provides the use of a compound of formula (I) R&#x2014;CO&#x2014;X) (Wherein R is a Cunsaturated hydrocarbon group optionally interrupted by &#x3b1;, &#x3b2;, &#x3b3;, or &#x3b4; to the carbonyl group by a heteroatom or group of heteroatoms selected from S, O, N, SO, SOsaid hydrocarbon group comprising at least 5 non-conjugated double bonds; and X is an electron withdrawing group) in the manufacture of a medicament for the treatment of psoriasis.

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Oslo, Norway

Lars Skattebol