Ludwig Institute for Cancer Research Limited

Lars Ronnstrand

Kohei Miyazono

Ulf G Hellman

Hidenori Ichijo

Christer Wernstedt

Carl-Henrik Heldin

Carl-Hendrik Heldin

The invention relates to a family of substantially pure, receptor like TGF-.beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells. Also described are nucleic acid sequences which code for the protein monomer making up the molecules.

Isolated nucleic acid encoding receptor-like TGF-.beta.1 binding protein

Substantially pure receptor like TFG-.beta.1 binding molecules

The invention relates to a family of substantially pure, receptor like TGF-.beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells.

Substantially pure receptor like TGF-.beta. 1 binding molecules and uses

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Upsala, Sweden

Lars Ronnstrand