Karolinska Innovations Ab

Astrazeneca Ab

Kampavata Ab

Lars Olson

Henrich Cheng

Nils-Göran Larsson

Mats Ekstrand

Silvia Burvenich

Andrea Carmine

Dagmar Galter

Olof Sydow

Nils-Göran Insför Medicinsk näringslära Larsson

The invention relates to a transgenic mouse model with deficient respiratory chain function in dopamine (DA) neurons. By suppressing or deleting the mitochondrial transcription factor A (Tfam) in DA neurons, a mouse model is obtained, which reproduces key pathophysiological features of Parkinson's disease (PD), i.e., slow progressive loss of DA terminals in striatum and loss of DA neurons in substantia nigra pars compacta; alpha-synuclein immunoreactivity including intracellular inclusions similar to Lewy bodies in affected areas prior to and during cell loss; progressive movement disorder associated with abnormal gait, tremor and rigid limbs. The mouse model can be used to develop pharmacological, gene therapy or cell therapy treatments for PD.

Transgenic non-human animal for use in research models for studying Parkinson's disease

The present invention relates to a method for identifying individuals with Parkinson's disease and/or individuals at risk for developing Parkinson's disease, comprising screening nucleic acids from the individual for a mutation in the ADHC gene, as well as different uses thereof.

ADH1C

A medical device ( ) of a biocompatible material for use in the treatment of a gap or defect in the central nervous system, which device has a proximal end ( ) and a distal end ( ) comprising openings ( ). The device is adapted to enable connection of nerve fibers of gray and white matter between the proximal end ( ) and distal end ( ) thereof in predetermined openings ( ). The device is of a substantially cylindrical form, or a substantially flat or plate like form and is made of plastic. The openings ( ) in at least one end ( ) bear distinctively different indicia thereby to indicate whether nerve fibers of gray matter or nerve fibers of white matter are to be inserted therein.

Medical device for treatment of a gap or defect in the central nerve system

A medical device (,) of a biocompatible material for use in the treatment of a gap or defect in the central nervous system, which device has a proximal end (,) and a distal end (,) comprising openings (,). The device is adapted to enable connection of nerve fibers of gray and white matter between the proximal end (,) and distal end (,) thereof in predetermined openings (,). The device is of a substantially cylindrical form, or a substantially flat or plate like form and is made of plastic. The openings (,) in at least one end (,) bear distinctively different indicia thereby to indicate whether nerve fibers of gray matter or nerve fibers of white matter are to be inserted therein.

Growing community of inventors

Lidingö, Sweden

Lars Olson