Nycomed Imaging As

Amersham Health As

Nyomed Imaging As

Lars Hoff

Jo Klaveness

P&aring;l Rongved

Alan Cuthbertson

Magne Solbakken

Sigmund Frigstad

Halldis Hellebust

Helge Tolleshaug

Anders H&oslash;gset

Morten Eriksen

Anne N&aelig;vestad

Dagfinn L&oslash;vhaug

Nils Sponheim

Knut Dyrstad

Klaus Bryn

Aslak Godal

Roald Skurtveit

Jonny &Oslash;stensen

Jonny O Slashedstensen

Jonny Ostensen

Morton Eriksen

Geir Gogstad

Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Diagnostic/therapeutic agents

Targeted diagnostic/therapeutic agents having more than one different vectors

A method of measuring tissue perfusion in a human or non-human animal subject which comprises administering an effective amount of an ultrasound contrast agent to said subject, irradiating tissue in a target region with at least one pulse of ultrasound having energy sufficient to destroy or discernibly modify the echogenic properties of substantially all contrast agent in said target region, and ultrasonically detecting and quantifying the rate of flow of either further contrast agent into said target region or modified contrast agent out of said target region.

Ultrasound imaging of tissue perfusion by pulse energy disruption of contrast agent

Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.

Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors

A contrast agent for use in diagnostic studies, particularly ultrasound imaging, comprising a dispersion in an injectable aqueous medium of a biocompatible azeotropic mixture which is in gaseous form at 37&deg; C., at least one component of said mixture being a halocarbon having a molecular weight of at least 100.

Contrast agents comprising an azeotropic mixture of two gases for ultrasound investigations

Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualize the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.

Ultrasound imaging

Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualise the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation arising from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.

Growing community of inventors

Oslo, Norway

Lars Hoff