Karo Bio Ab

Karo Pharma Ab

Lars Hagberg

Philip R Kym

James T Link

Russell Drew Cink

Chunqiu Lai

Marvin Robert Leanna

Noah Tu

Richard D Bishop

Bradley D Gates

Aiping Cheng

Tom W Von Geldern

Peer B Jacobsen

Steven J Richards

Joakim Löfstedt

Konrad Koehler

Theresa Apelqvist

Neeraj Garg

Lars Krüger

Sandra Gordon

Patrik Rhönnstad

Mattias Wennerstål

Daniel Nöteberg

Eva Koch

Lars KRÜGER

Joakim LÖFSTEDT

Daniel NÖTEBERG

Mattias WENNERSTÅL

Patrik RHÖNNSTAD

Compounds of formula (I) or a pharmaceutically acceptable ester, amide, carbamate or salt thereof, including a salt of such an ester, amide or carbamate in which Rto Rhave meanings as defined in the Specification, are useful as estrogen receptor ligands. 

Estrogen receptor ligands

The invention provides a compound of formula(I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula(I) wherein R, R, R, R, R, R, R, R, Rand Rare as defined in the specification. 

This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

Glucocorticoid receptor ligands for the treatment of metabolic disorders

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Stockholm, Sweden

Lars Hagberg