Cambrex Karlskoga Ab

Spinchem Ab

Cambrex Profarmaco Milano

I-tech Ab

Lars Eklund

Knut Irgum

Emil Byström

Ants Maasalu

Malle Schmidt

Lars O Hansson

Margus Eek

Henrik Scherman

Stefano Radaelli

Giuseppe Zurlo

Jonas Nilsson

Lars Hansson

Tommy Lundholm

Pär Holmberg

Ramesh Ekambaram

Birger Hagberg

Anders Bergh

The invention refers to a reactor and a method respectively for performing, by means of solid reaction members, a biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic media, and a subsequent cleaning of the reactor, said reactor comprising a vessel () in which a transformation device () has been mounted. The invention also refers to a reactor kit comprising such reactor. The reactor comprises at least one nozzle () arranged on the longitudinal inner wall of the vessel (). The at least one nozzle () is arranged to direct a flow of a cleaning fluid (CF) in a direction towards a longitudinal centre axis (L) of a flow distributor () arranged in the vessel ().

Reactor comprising a nozzle for cleaning fluid, a kit and a method

The present invention relates to the field of biological and chemical transformation as well as physical and chemical trapping. More specifically, the invention relates to a new reactor arrangement for performing, by means of at least one solid reaction member, biological or chemical transformation, or physical or chemical trapping from or release of agents to, a fluidic medium. The reactor arrangement is comprised of an auxiliary reactor having a transformation device and a main reactor. The invention also provides an auxiliary reactor adapted for being connected to a main reactor, a method of using such a reactor arrangement, as well as a process involving the reactor arrangement.

Auxiliary reactor for biological or chemical transformation

There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent. 

Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine

There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application. 

Process for preparing lacosamide and related compounds

There is provided a process for the preparation of a compound of formula I, wherein X, R, R, R, R, R, R, R, R, R, Rand Rare as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).

Processes for producing benzophenone derivatives

There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves. 

Processes for preparing 4-substituted imidazoles

There is provided a process for the preparation of a compound of formula (I), wherein R, R, R, R, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. 

Process for preparing benzofurans

There is provided a process for the preparation of a compound of formula (I), wherein R, R, R, R, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. Intermediate steps of the process comprise formulae according to (II) and (III). 

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Karlskoga, Sweden

Lars Eklund