Aktiebolaget Hassle

Lars Ek

Stig Ake Carlsson

Peder Bernhard Berntsson

Benny Roger Samuelsson

Gert Christer Strandlund

Enar Ingemar Carlsson

Arne Elof Brandstrom

Bengt Arne Ablad

Sven Erik Sjostrand

Arne E Brandstrom

Enar I Carlsson

Gert C Strandlund

Sven E Sjostrand

Gustav Benny Samuelsson

Sven Erik Sjastrand

Bengt A Ablad

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

Phenoxy-hydroxypropylamines, their preparation, and method and

New amines of the formula ##STR1## wherein the radicals R.sup.1, R.sup.2 and R.sup.3 may be any of a variety of groups described below, several methods for preparing them and the use thereof in the treatment of cardiovascular diseases, particularly in blocking cardial and vascular beta-receptors.

Phenoxy propanolamines

Substituted ureido alkylene phenoxy propanolamines

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxy alkyl, R.sup.2 is alkoxyalkyl, alkylthioalkyl, alkoxycarbonylaminoalkyl, or alkoxyalkoxy, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed as are methods for their preparations; Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

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Kungsbacka, Sweden

Lars Ek