Novo Nordisk A/s

Novo Nordisk Healthcare Ag

Lars Eilertsen

Henrik Bengtsson

Morten Revsgaard Frederiksen

Ruben Archilla

Soeren Dyring Jensen

Mattias Ingerslev

Christian Plambech

Bo Radmer

Matias Melander

Jim Radmer

Christian Hoejris Nielsen

Simon Munch Pedersen

Jonas Hjortlund

Mads Schenstroem Stefansen

Klaus Bendix

Jeppe Sturis

Bjoern Gullak Larsen

Jonas Kildegaard Pedersen

Ulla Ribel-Madsen

Ronan Carroll

Emil Gram Spork

Thomas Bjarnsholt

Kurt Solgaard

Henning Graaskov

Rikke Bjerring Andersen

Henning Gråskov

Claus Moser

Casper Bo Jensen

Frederik Kaae Kirk

Kezia A Juul

Martin Rasmussen

Rasmus Kann Jensen

Mads Schenstrøm Stefansen

Christian Højris Nielsen

Rubén Archilla

Josefine Carlsson

Søren Dysing Jensen

The present invention concerns a medical injection device for apportioning set doses of a preservative containing liquid drug. The injection device comprises a housing supporting a cartridge containing the preservative containing liquid drug and a needle cannula for transferring the liquid drug from the cartridge and through the skin of a user. Further, a needle shield which is axially movable in relation to the housing is also present. The axially movable shield carries a cleaning reservoir for cleaning at least the tip of the needle cannula between subsequent injections and the cleaning reservoir is preferably filled with preservative containing liquid drug directly from the cartridge upon initiation of the injection device. In order to eliminate any overpressure being built up inside the cleaning reservoir during the filling process, the cleaning reservoir is provided with an outlet configured to be permanently sealed by a user activated operation.

Medical injection device having a sealable cleaning reservoir

The present invention relates to a pre-filled disposable injection device and a needle cannula in combination. The prefilled disposable injection device () is made from a housing () containing a non-exchangeable cartridge () for storing a liquid drug sufficient for a number of injections. The proximal end of the pre-filled injection device () carries the dose setting button () and the distal end carries the needle cannula () having a lumen () through which the settable dose is expelled. The distal end () of the needle cannula () is covered by a telescopic needle covering shield () which shield () can operate between a first position covering the tip () of the needle cannula () and a second retracted position allowing an injection to be performed. The shield () carries a cleaner () which cleans at least the tip () of the needle cannula () between successive injections such that the prefilled injection device can be used without changing the needle cannula () during its life cycle.

Pre-filled disposable injection device

The invention relates to a prefilled injection pen for apportioning multiple set doses of a liquid drug. The injection pen comprises a housing assembly with a removable cap rotatable coupled to the housing assembly such that the user has to rotate the removable cap upon mounting and dismounting the removable cap. Rotation of the removable cap initiates a process in which the proximal end of a needle cannula is first inserted into a cartridge permanently embedded in the housing assembly and thereafter moves the cartridge proximally to thereby pump a predetermined amount of the preservative containing liquid drug from the cartridge and into a cleaning chamber carried by an axially movable shield. The needle cannula is mounted in a needle hub which is arranged to follow rotation of the removable cap and guided helically in relation to the housing assembly such that the needle hub is moved proximally upon rotation of the removable cap. Further, the axially movable shield is operated by the needle hub to follow proximal movement of the needle hub such that the distal tip of the needle cannula is maintained inside the cleaning chamber upon axil movement of the needle hub and the needle cannula.

Medical injection device with needle cleaning

The invention relates to a pre-filled injection device for apportioning a plurality of set doses of a liquid drug comprising. The housing of the injection device supports a non-replaceable cartridge containing the liquid drug. The cartridge is e.g. secured in a cartridge-holder being a part of the housing. A needle assembly comprising a needle cannula secured in a hub is slidable mounted to slide into contact with the cartridge. The tip of the needle cannula is covered by a telescopically movable shield movable from an extended position to a retracted position. The telescopically movable shield supports a cleaning chamber containing a cleaning solvent for cleaning at least the distal tip of the needle cannula between subsequent injections. The distal end of the housing supports a removable protective cap and the telescopically movable shield is guided relatively to the housing and coupled to the protective cap to follow movement of the protective cap.

Medical injection device having a telescopically movable shield

The present invention provides an injection needle unit () comprising: a needle assembly () comprising: an injection needle () extending along a longitudinal axis and having a distal needle end configured for insertion into a subject and a proximal needle end configured for penetration of a reservoir septum, and a skirt () surrounding the proximal needle end and defining a receiving space () for reception of a needle mount of a drug delivery device, the skirt () comprising a slot (), and a block structure () supported exteriorly of the skirt (), wherein the block structure () is biased towards the longitudinal axis and is capable of radial displacement through the slot () from a latched position outside the receiving space () to a released position within the receiving space ().

Needle unit for drug delivery device

The present invention relates to an injection device for injecting a pharmaceutical liquid drug containing a preservative. The injection device comprises a housing () supporting a cartridge () having an interior chamber () holding the pharmaceutical preservative containing liquid drug to be injected, and a needle cannula () having a front part () and a back part (), which back part () is adapted to be in liquid communication with the interior chamber () of the cartridge (). The injection device is further provided with a telescopic needle covering shield () which distally is provided with a reservoir () which holds a liquid containing the same preservatives as in the pharmaceutical preservative containing liquid drug contained in the interior chamber of the cartridge. The telescopic needle covering shield () is telescopic movable in relation to the needle cannula () by a first resilient member between a first position and a second position. In the first position, the tip () of the front part () of the needle cannula () is maintained inside the reservoir (), and in the second position, the tip () of the front part () of the needle cannula () is located outside the reservoir () and distally to the reservoir (). The tip () of the needle cannula () is thus cleaned by the preservatives in the reservoir () between subsequent injections.

Injection device with a needle cannula

The present invention relates to a needle arrangement for an injection device. The needle arrangement is made up from needle cannula which is mounted such that a distal part having a distal tip extends in a distal direction. Further, a telescopically movable shield carrying a cleaning chamber surrounds at least the tip of the needle cannula between injections such that the tip of the needle cannula is maintained inside the cleaning chamber between subsequent injections. The cleaning chamber is at least distally provided with a pierceable septum through which the needle cannula penetrates during injections. For guiding the needle cannula during injections a telescopically movable tube is provided. During injections the distal end of the telescopically movable tube at least partly penetrates the distal septum.

Needle arrangement

The present invention relates to a needle assembly having a build-in valve (). The needle assembly is built up from a hub () carrying a needle cannula () and a telescopically movable shield () which axially covers the distal tip () of the needle cannula () between injections. The valve () is operated by the shield () and is arranged such that it is closed when the distal tip () of the needle cannula () is covered by the shield () and is opened when the telescopically movable shield () has been retracted a specific distance (X) proximally to the distal tip () of the distal cannula part ().

Injection needle having shield activated valve

A drug delivery assembly includes a housing (), a piston () axially displaceable in the housing, and a variable volume reservoir () formed by the housing and the piston and containing a fluid first drug. The assembly further includes an exterior fluid inlet () arranged in or configured to be arranged in fluid communication with the reservoir, a fluid outlet () arranged in or configured to be arranged in fluid communication with the reservoir, biasing means () configured for moving the piston forwards, and releasable retaining means () configured for retaining the piston in an initial position, whereby the biasing means is allowed to move the piston forwards to expel fluid drug from the reservoir when the retaining means is released.

Drug filled delivery assembly

The present invention relates to a medical device () comprising a first container () holding a first medium and defining a general axis, a second container () holding a second medium, and fluid connection means () for establishing fluid connection between the first container () and the second container (), the fluid connection means () being arranged at least partially between the first container () and the second container (). The device further comprises a cover receiving portion () and a cover () removably mounted thereon to shield at least an operable portion of the first container (). The cover () is operatively coupled with the fluid connection means () and configured to cause a relative converging motion between at least one of the first container () and the fluid connection means () and the second container () and the fluid connection means () in response to a dismounting of the cover () from the cover receiving portion ().

Pre-assembled fluid transfer arrangement

Growing community of inventors

Fredensborg, Denmark

Lars Eilertsen