Exelixis, Inc.

Other

Exelixus, Inc.

Larry Wayne Mann

Timothy Patrick Forsyth

James William Leahy

John M Nuss

Lynne Canne Bannen

Yong Wang

Jeff Z Chen

Grace Mann

Lisa Esther Dalrymple

Richard George Khoury

Jason Jevious Parks

Tai Phat Huynh

Craig Stacy Takeuchi

Diva Sze-Ming Chan

Vasu Jammalamadaka

Morrison B Mac

Wie Xu

Morrisson B Mac

Sergey Epshteyn

Wei Xu

Brian Hugh Ridgway

Joan C Sangalang

Mohamed Ibrahim

Xian Shi

Kevin Luke Schnepp

Raju Mohan

Matthew A Williams

Richard Martin

Tie-Lin Wang

Brenton Todd Flatt

Atwood Kim Cheung

Xiao-Hui Gu

Michael Charles Nyman

Gary Lee Lewis

Robin Tammie Noguchi

Jason H Wu

Brett Murphy

Jeff Chen

William C Stevens

Neel Kumar Anand

Tsze Tsang

Csaba J Peto

David J Matthews

Kenneth D Rice

Abigail R Kennedy

Longcheng Wang

S David Brown

Peter Lamb

Larisa Dubenko

Erick Wang Co

Chris Allen Buhr

Sunghoon Ma

William C Stevens, Jr

Wei Cheng

Tae-Gon Baik

Zerom Tesfai

Baili Chen

Lisa Esther Dalrymple Meyr

Nicole Miller

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

C-met modulators and methods of use

c-Met modulators and methods of use

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

C-met modulators and method of use

c-Met modulators and method of use

Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

Pyrrole derivatives as pharmaceutical agents

The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NRR, or O&#x2014;R, wherein X is H, halo, C-Calkyl, NO, mono-, di-, or tri-halo substituted methyl, NRR,. C(O)O&#x2014;C-Calkyl, or N(R)&#x2014;C(O)&#x2014;C-Calkyl; Y is H, halo, OH, C-Calkyl, C-Calkyl-NR,R, NRR,, C-Calkoxy, &#x2014;N(R)&#x2014;(CH)NRR, &#x2014;C(O)O&#x2014;C-Calkyl, &#x2014;O&#x2014;(CH)&#x2014;NRR, &#x2014;C(O)&#x2014;C-Calkyl, &#x2014;C-C-alkyl-R, &#x2014;O&#x2014;R, &#x2014;C(O)&#x2014;R, &#x2014;O&#x2014;(CH)&#x2014;R, &#x2014;C(O)&#x2014;NRR, &#x2014;C(O)&#x2014;N(R)-aryl, &#x2014;C(O)&#x2014;N(R)(CH)&#x2014;NRR, &#x2014;C(O)&#x2014;N(R)&#x2014;(CH)-aryl &#x2014;C(O)&#x2014;N(R)&#x2014;(CH)-heterocyclyl; or X and Y together with the atoms to which they are attached form a 4-7 membered heterocyclyl or heteroaryl group containing one or two heteroatoms independently selected from O, N, and S. Z is H, NRR, &#x2014;S&#x2014;R, or &#x2014;O&#x2014;R 

Pyrimidine derivatives as kinase modulators and method of use

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Tie-2 modulators and methods of use

A compound for modulating kinase activity according to Formula I, or a pharmaceutically acceptable salt thereof, Wherein J, J, J, R, J, Z, Ar and Rare as defined in the specification, compositions thereof, and methods of use thereof.

c-MET modulators and method of use

This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

Protein kinase modulators and methods of use

An apparatus and method for injecting a boat engine's exhaust gasses into the boat propeller's propwash, aft of the propeller. The apparatus comprises piping which injects the boat engine's exhaust gasses into the propwash of the boat, aft of the propeller. This results in the movement of the exhaust gasses away from the boat thus protecting the health of the boat occupants, reduced levels of air pollutants, and a reduction in noise pollution. The injection piping includes several features that protect the boat in the event that the injection piping should strike a solid object in the water.

Apparatus and method for boat engine exhaust injection system

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Richland, MI, United States of America

Larry Wayne Mann