Eli Lilly and Company

Larry W Hertel

Julian Stanley Kroin

Charles David Jones

Thomas Edward Mabry

Yao-Chang Xu

Gerald B Grindey

Cora Sue Grossman

Paul Leslie Ornstein

Michael J Martinelli

John Michael Morin, Jr

Matthew Joseph Fisher

David T Wong

Ta-Sen Chou

Qing Shi

Daniel Timothy Kohlman

Sidney Xi Liang

Karin Briner

Kenneth Lee Hauser

Richard E Holmes

Robert Theodore Vasileff

Timothy Ivo Richardson

Vincent Mancuso

Zhipei Wu

Christopher William Doecke

John Philip Mayer

Chaoyu Xie

Jikesh Arvind Shah

Marie T Reamer

Christopher Kelly Biggers

The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction 

Melanocortin receptor agonists

The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT receptor and antagonizing the 5-HT receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

Azepine derivatives having effects on serotonin related systems

Piperidine derivatives having effects on serotonin related systems

Pyrrolidine and pyrroline derivatives having effects on serotonin related systems

A stereoselective anion glycosylation process for preparing beta- and alpha-anomer enriched 2', 2'-difluoro-2'-deoxynucleosides and 2'-deoxy-2'-fluoronucleosides by reacting an alpha- or beta-anomer enriched 2-deoxy-2-fluorocarbohydrate or 2-deoxy-2,2-difluorocarbohydrate with at least a molar equivalent of a salt of a nucleobase derivative in an inert solvent.

Stereoselective anion glycosylation process for preparing

This invention provides 2',3'-dideoxy-2',2'-difluoronucleosides of the structure ##STR1## wherein R.sup.1 -R.sup.4 are defined in the specification. These compounds have been shown to be useful for treating a variety of vital infections in experimental animals as well as having antineoplastic activity against various mouse tumors.

2',3'-dideoxy-2',2'-difluoronucleosides and intermediates

Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.

Anomeric fluororibosyl amines

2',3'-Dideoxy-2',2'-difluoronucleosides are useful for treating susceptible neoplasms and viral infections in mammals.

Methods of treatment using 2',3'-dideoxy-2',2'-difluoronucleosides

A method of treating susceptible neoplasms in mammals comprising administering to a mammal in need of such treatment a pharmaceutically effective amount of a compound of the formula ##STR1## wherein: R.sup.1 is hydrogen;

Method of treating tumors in mammals with 2',2'-difluoronucleosides

The invention provides certain 2-Deoxy-2,2-Difluoro (4-Substituted) Pyrimidine Nucleosides that are effective as anti-cancer agents and in treating viral infections.

2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, bicyclic

A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.

Difluro antivirals and intermediate therefor

2'-deoxy-2',2'-difluoro-inosine and 5'-O alkyl derivatives are disclosed as inhibitors of neoplasms.

2-deoxy-2',2'-difluoro-inosine and 5'O-derivatives

Difluoro antivirals and intermediate therefor

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Indianapolis, IN, United States of America

Larry W Hertel