Abbott Laboratories Corporation

Larry T Mimms

William Frederick Carman

Richard H Decker

Larry R Solomon

Lesley Wallace

Suresh M Desai

Joan D Tyner

Sushil G Devare

Smriti U Mehta

Jill E Johnson

Sheela M George

Mary S Gibadlo

Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

Hepatitis B virus mutants, reagents and methods for detection

Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatitis C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

Monoclonal antibodies to hepatitis C virus and method for using same

Hepatitis B Virus mutants, reagents and methods for detection

This invention relates to improved 'sandwich' immunoassays for antibodies in body fluids of the type where antigen specific for the antibody to be detected is disposed on a solid support and binds antibody from the body fluid, from which the antibody bound to the solid support is detected by a labeled antigen to the antibody to be detected. The improvement comprises using antigens from heterologous cell sources.

Immunoassays using antigens produced in heterologous organisms

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Lake Villa, IL, United States of America

Larry T Mimms