The Ohio State University

Ohio State Innovation Foundation

Other

Cardinal Health 414, LLC

Larry Schlesinger

Ching-Shih Chen

Hao-Chieh Chiu

John S Gunn

Dasheng Wang

Samuel K Kulp

Eric M Bachelder

Frederick O Cope

Abul K Azad

Benjamin Kopp

Santosh Salunke

Fred Cope

Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.

Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis

Compositions and methods for preventing and treating infection with multi-drug resistant bacteria with AR-13 alone or in combination with antibiotics are provided.

Compositions and methods for inhibiting the growth of multi-drug resistant microbes

Methods of treating bacterial infection by in a subject by administering a pharmaceutical composition including a celecoxib derivative are described. The compounds are particularly useful for treating infection by bacteria capable of growing inside macrophages, such as

Antibacterial protein kinase inhibitors

A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection byin a subject are described.

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A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is &#x2014;CF, Ar is selected from and R is selected from  

Anti-infective agents against intracellular pathogens

A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is &#x2014;CF, Ar is selected from and R is selected from where 

Growing community of inventors

Powell, OH, United States of America

Larry Schlesinger