Sunovion Pharmaceuticals Inc.

Larry R Bush

Liming Shao

Michael Charles Hewitt

Jianguo Ma

Fengjiang Wang

Una Campbell

Scott C Malcolm

Larry Wendell Hardy

Patrick Koch

Mark A Varney

Sharon Rae Engel

John Emmerson Campbell

John E Campell

Scott Christopher Malcolm

The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

Cycloalkylamines as monoamine reuptake inhibitors

The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.

Tetralone-based monoamine reuptake inhibitors

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Worcester, MA, United States of America

Larry R Bush