Eastman-Kodak Company

Nanosystems L.l.c.

Eastman Kodak

Larry P Seaman

David A Czekai

Dennis E Smith

Huijuan D Chen

Gang C Han-Adebekun

A color set for forming an ink jet image comprising:

Ink jet ink set

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.

Method of grinding pharmaceutical substances

A continuous method of preparing submicron particles of a therapeutic or diagnostic agent comprises the steps of continuously introducing the agent and rigid grinding media into a milling chamber, contacting the agent with the grinding media while in the chamber to reduce the particle size of the agent, continuously removing the agent and the grinding media from the milling chamber, and thereafter separating the agent from the grinding media. In a preferred embodiment, the grinding media is a polymeric resin having a mean particle size of less than 300 .mu.m. In another preferred embodiment, the agent, grinding media and a liquid dispersion medium are continuously introduced into the milling chamber. In a further embodiment, the agent and grinding media are recirculated through the milling chamber. The method enables the use of fine grinding media, e.g., of a particle size of less than about 300 .mu.m, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the separation of agent from the grinding media in the milling chamber.

Continuous method of grinding pharmaceutical substances

A method of preparing milled solid particles of a compound comprises the steps of forming a slurry of a liquid medium, the compound and rigid milling media in a milling chamber, contacting the compound with the milling media while in the chamber to reduce the particle size of the compound, and thereafter separating the compound from the milling media by vacuum filtration through a removable filter probe immersed in the slurry. In a preferred embodiment, the milling media is a polymeric resin having a mean particle size of less than 300 .mu.m. The method enables the use of fine milling media which provides extremely fine particles of the compound while avoiding problems, e.g., decrease yields due to separator screen plugging, associated with prior art processes.

Process for milling and media separation

A continuous method of preparing submicron particles of a compound useful in imaging elements (or other materials, such as pigments, etc.) comprises the steps of continuously introducing the compound and rigid milling media into a milling chamber, contacting the compound with the milling media while in the chamber to reduce the particle size of the compound, continuously removing the compound and the milling media from the milling chamber, and thereafter separating the compound from the milling media. In a preferred embodiment, the milling media is a polymeric resin having a mean particles size of less than 300 .mu.m. The method enables the use of fine milling media in a continuous milling process which provides extremely fine particles of the compound useful in imaging elements while avoiding problems, e.g., separator screen plugging associated with prior art processes requiring the separation of compound from the milling media in the milling chamber.

Continuous media recirculation milling process

A method of preparing submicron particles of a material, such as a pigment useful in paints or a compound useful in imaging elements, which comprises milling the agent in the presence of milling media having a mean particle size of less than about 100 microns. In a preferred embodiment, the milling media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nm in size, free of unacceptable contamination.

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Mount Morris, NY, United States of America

Larry P Seaman