Minnesota Mining and Manufacturing Company

Terumo Cardiovascular Systems Corporation

Larry M Sirvio

Todd R Williams

Dee Lynn Johnson

David F Wirt

Barbara C Swenson

Therese A Senta

David C Muchow

A process for modifying a surface of an article that includes treating a surface with a solution that includes an organic solvent, and the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a modified surface.

Process for modifying surfaces using the reaction product of a

A process for modifying a surface of an article that includes treating the surface with (a) a first water-soluble polyalkylene amine, (b) a water-soluble polymeric anionic compound, and (c) a second water-soluble polyalkylene amine in the absence of crosslinking agents to create a modified surface.

Process for modifying surfaces

A device useful for the treatment of infections of the middle ear in a prophylactic manner. A preferred device involves the use of a biodegradable support incorporating a therapeutically active agent, such as a drug. The device can be surgically inserted into the middle ear and there expand in order to substantially contact the walls of the middle ear. As it biodegrades, the expanded device provides prolonged, responsive release of active agent to the middle ear.

Device and method for extended delivery of pharmacologically active

Topical therapeutic compositions are disclosed which contain from about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide and a therapeutic agent selected from the group consisting of erythromycin, benzoyl peroxide, hydrocortisone, tetracycline, 5-fluorouracil, and propranolol. The amine oxide enhances penetration of the therapeutic agent into and through the skin.

Topical medicament preparations

Geminal prostaglandins (P.G.'s) are synthesized which are represented by the general formula: ##STR1## where A is a 4 or 5 carbon atom ring-completing group (CH.sub.2).sub.1+m --X--(CH.sub.2).sub.z where m = 0, 1 or 2,

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Cottage Grove, MN, United States of America

Larry M Sirvio