Acelrx Pharmaceuticals, Inc.

Acelrx Pharmaceutical, Inc.

Larry Hamel

Stelios Tzannis

Andrew I Poutiatine

Pamela Palmer

Thomas A Schreck

Bruce P Edwards

Charles Rampersaud

Edmond Chiu

Evangeline Cruz

Shamim Pushpala

Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.

Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain

Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Methods for administering small volume oral transmucosal dosage forms using a dispensing device

Compositions and methods effective to minimize or eliminate the presence of oxidative degradation products in solid dosage forms comprising sufentanil are provided.

Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same

Bioadhesive drug formulations that adhere to an oral mucosal membrane of a subject are provided together with single dose applicators and devices for delivering the drug formulations to the oral mucosa, and methods for using the same.

Bioadhesive drug formulations for oral transmucosal delivery

Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.

Small-volume oral transmucosal dosage forms or NanoTabs&#xae; comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs&#xae; to administer a drug for the treatment of acute, post-operative or breakthrough pain.

Small-volume oral transmucosal dosage forms

A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.

Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms

Formulations for controlled delivery of oral transmucosal medications are provided. The formulations are characterized as hydrogel-forming or eroding-types which are bioadhesive and provide for controlled and sustained release of the medication such that enhanced bioavailability and efficacy is provided.

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Mountain View, CA, United States of America

Larry Hamel