Nanosys, Inc.

Larry Bock

Stephen A Empedocles

Linda T Romano

David P Stumbo

Vijendra Sahi

R Hugh Daniels

George Pontis

Xianfeng Duan

Chunming Niu

Calvin Y H Chow

Calvin Y Chow

John C Owicki

Chungming Niu

Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.

Nano-chem-FET based biosensors

Methods of detecting components of interest, e.g., nucleic acids and sugars, are provided. The methods comprise contacting one or more nanowires comprising a functional group with a sample containing the component or components of interest. In one embodiment, the functional group comprises a hairpin oligonucleotide, e.g., a hairpin that changes conformation upon binding the component of interest, e.g., a nucleic acid. The change in conformation produces a change in charge that is detected. In another embodiment, the functional group comprises an enzyme, e.g., glucose oxidase, which produces a change in pH when glucose is present in a sample.

Nanostructure manufacturing methods and methods for assembling nanostructures into functional elements such as junctions, arrays and devices are provided. Systems for practicing the methods are also provided.

Methods of making, positioning and orienting nanostructures, nanostructure arrays and nanostructure devices

Growing community of inventors

Olivenhain, CA, United States of America

Larry Bock