Genzyme Corporation

Larry A Couture

Richard J Gregory

Alan E Smith

Donna Armentano

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

Adenovirus vectors for gene therapy

Gene therapy for cystic fibrosis

Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide for a second generation of adenoviral vectors that contain the 5' ITR's, the packaging signal and the E1A enhancer. Other adenoviral vectors contain a deletion of the E1 region or a deletion of E4 but retain orf3 or orf6, and can either retain or delete the E3 region.

Growing community of inventors

Louisville, CO, United States of America

Larry A Couture