Washington University

Beth Israel Deaconess

Larissa Thackray

David Huabin Wang

Herbert W Virgin

Guoyan Zhao

Dan H Barouch

Daved Henry Fremont

Christopher Nelson

Scott Handley

Rachel Presti

Joy Loh

Thad Stappenbeck

Christine Yokoyama

Arthur Kim

Katherine Basore

Rong Zhang

Among the various aspects of the present disclosure is the provision of compositions and methods of treating arthritogenic alphavirus infection and methods of screening.

Compositions and methods for inhibition of alphavirus infection

The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.

Viruses associated with immunodeficiency and enteropathy and methods using same

Novel murine astroviruses, and methods of detecting the viruses are disclosed. Also disclosed are uses of the viruses and infected animals as model systems for discovery and development of vaccines and therapies for diseases caused by or associated with astrovirus infection, including human astrovirus-based diseases.

Methods of murine astrovirus detection

Growing community of inventors

Columbia, IL, United States of America

Larissa Thackray